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What is Algofren?

Algofren is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain, and helps to relieve symptoms of arthritis (osteoarthritis, rheumatoid arthritis, or juvenile arthritis), such as inflammation, swelling, stiffness, and joint pain. Algofren does not cure arthritis and will help you only as long as you continue to take it.

In addition, Algofren can be used to treat fever, menstrual cramps, and other conditions as determined by your doctor.

Algofren is available both over-the-counter (OTC) and with your doctor’s prescription.

ALGOFREN INDICATIONS

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol.

Carefully consider the potential benefits and risks of Algofren

Oral Suspension and other treatment options before deciding to use Algofren. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.

In Pediatric Patients, Algofren

Oral Suspension is indicated:

  • For reduction of fever in patients aged 6 months up to 2 years of age.
  • For relief of mild to moderate pain in patients aged 6 months up to 2 years of age.
  • For relief of signs and symptoms of juvenile arthritis.

In Adults, Algofren

Oral Suspension is indicated:

  • For treatment of primary dysmenorrhea.
  • For relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis.

Since there have been no controlled trials to demonstrate whether there is any beneficial effect or harmful interaction with the use of Algofren in conjunction with aspirin, the combination cannot be recommended.

HOW SHOULD I USE ALGOFREN?

Use Algofren capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Algofren capsules comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Algofren capsules refilled.
  • Take Algofren capsules by mouth with or without food. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.
  • Swallow Algofren capsules whole. Do not break, crush, or chew before swallowing.
  • Take Algofren capsules with a full glass of water (8 oz/240 mL) as directed by your doctor.
  • If you miss a dose of Algofren capsules and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about the proper use of Algofren capsules.

USES OF ALGOFREN IN DETAILS

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition.

Algofren is used to relieve pain from various conditions such as headache, dental pain, menstrual cramps, muscle aches, or arthritis. It is also used to reduce fever and to relieve minor aches and pain due to the common cold or flu. Algofren is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body’s production of certain natural substances that cause inflammation. This effect helps to decrease swelling, pain, or fever.

If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain. See also Warning section.

This form of Algofren is intended for use by children. Do not give this medication to a child younger than 6 months unless directed by the doctor.

Check the ingredients on the label even if you have used the product before. The manufacturer may have changed the ingredients. Also, products with similar names may contain different ingredients meant for different purposes. Taking the wrong product could harm you.

How to use Algofren

Read and follow all directions on the product package before using this medication. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor or the package label, usually every 6 to 8 hours as needed. Shake the bottle well before each dose. Carefully measure the dose using the provided dropper/syringe. Do not use a household spoon because you may not get the correct dose. If you have stomach upset while taking this medication, take it with food or milk.

Algofren does not cure arthritis and will help you only as long
Algofren does not cure arthritis and will help you only as long

The dosage is based on your medical condition and response to treatment. To reduce your risk of stomach bleeding and other side effects, take this medication at the lowest effective dose for the shortest possible time. Do not increase your dose or take this drug more often than directed by your doctor or the package label.

When Algofren is used by children, the dose is based on the child’s weight. Read the package directions to find the proper dose for your child’s weight. Consult the pharmacist or doctor if you have questions or if you need help choosing a nonprescription product.

If you are using this drug “as needed” (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

If your condition persists or worsens, or if you think you may have a serious medical problem, get medical help right away. If you are using the nonprescription product to treat yourself or a child for fever or pain, consult the doctor right away if fever worsens or lasts more than 3 days, or if pain worsens or lasts more than 10 days.

Algofren is a member of the propionic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). It is a racemic mixture of [+]S- and [-]R-enantiomers.

The chemical name for Algofren is (±)-2-(4-isobutylphenyl) propionic acid. It has a molecular weight of 206.28 and a molecular formula of C13H18O2.

Algofren is a colorless, crystalline stable solid, with a melting point of 75-77°C. It is relatively insoluble in water but readily soluble in most organic solvents. Algofren has a pKa of 4.43±0.03 and an n-octanol/water partition coefficient of 11.7 at pH 7.4.

Algofren has shown analgesic, anti-inflammatory and antipyretic activity in both animal and human studies. These properties provide symptomatic relief of inflammation and pain.

ALGOFREN DOSAGE

Recommended Dose

A course of therapy is three doses of Algofren administered intravenously (administration via an umbilical arterial line has not been evaluated). An initial dose of 10 mg per kilogram is followed by two doses of 5 mg per kilogram each, after 24 and 48 hours. All doses should be based on birth weight. If anuria or marked oliguria (urinary output < 0.6 mL/kg/hr) is evident at the scheduled time of the second or third dose of Algofren, no additional dosage should be given until laboratory studies indicate that renal function has returned to normal. If the ductus arteriosus closes or is significantly reduced in size after completion of the first course of Algofren, no further doses are necessary. If during continued medical management the ductus arteriosus fails to close or reopens, then a second course of Algofren, alternative pharmacological therapy, or surgery may be necessary.

Directions For Use

For intravenous administration only.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit. Do not use Algofren if particulate matter is observed.

After the first withdrawal from the vial, any solution remaining must be discarded because Algofren contains no preservative.

For administration, Algofren should be diluted to an appropriate volume with dextrose or saline. Algofren should be prepared for infusion and administered within 30 minutes of preparation and infused continuously over a period of 15 minutes. The drug should be administered via the IV port that is nearest the insertion site. After the first withdrawal from the vial, any solution remaining must be discarded because Algofren contains no preservative.

Since Algofren is potentially irritating to tissues, it should be administered carefully to avoid extravasation.

Algofren should not be simultaneously administered in the same intravenous line with Total

Parenteral Nutrition (TPN). If necessary, TPN should be interrupted for a 15-minute period prior to and after drug administration. Line patency should be maintained by using dextrose or saline.

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